By Joachim R. Kalden, Martin Herrmann
This can be the 1st complete e-book in regards to the courting among apoptosis and autoimmune ailments. It deals a different updated evaluation on learn effects at the faulty execution of apoptosis and the unfinished clearance of apoptotic cells. The molecular and mobile mechanisms concerned are defined intimately. As a potential outcome of apoptotic disorder, the improvement of critical autoimmune illnesses (e.g., rheumatoid arthritis, systemic lupus erythematosus) is mentioned. An outlook on destiny learn subject matters contains the assessment of novel healing recommendations.
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Extra info for Apoptosis and Autoimmunity: From Mechanisms to Treatments
Furthermore, caspase-11 knockout mice were found to have significant resistance to development of MOG peptide-induced experimental autoimmune encephalitis . In addition, caspase-11 is able to activate caspase-1 and -3 by direct cleavage in vitro . Although these data may indicate that caspase-11 is important in apoptosis via modulation of caspase-3 activation, it has remained difficult to definitively separate this effect from alterations in cytokine levels seen in caspase-11 knockouts.
Differential activation requirements for virgin and memory T cells. J Immunol 1988, 141, 3249–57. , Edwards, C. , Bluethmann, H. and Mountz, J. D. Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I. J Immunol 1996, 156, 2661–5. Cohen, P. L. and Eisenberg, R. A. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol 1991, 9, 243–69. , Zheng, T. , Rakic, P. and Flavell, R A. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.
Bratton, D. L. and Henson, P. M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 1992, 148, 2207–16. Thornberry, N. , Bull, H. , Calaycay, J. , Chapman, K. , Howard, A. , Kostura, M. , Miller, D. , Molineaux, S. , Weidner, J. , et al. A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 1992, 356, 768–74. Stennicke, H. R. and Salvesen, G. S. Catalytic properties of the caspases.
Apoptosis and Autoimmunity: From Mechanisms to Treatments by Joachim R. Kalden, Martin Herrmann