By Jürgen Harder, Jens-M. Schröder
This e-book specializes in the significance of human antimicrobial peptides (AMP) in conserving the host fit and fighting infectious ailments. the 1st chapters care for a number of examples of the function of AMP in several epithelial organs (skin and wound therapeutic, eye, lung, genito-urinary tract, gut), that are uncovered to other forms of infectious microorganisms and therefore produce varied styles of AMP. Examples of the dysregulation of AMP expression and serve as selling infections are mentioned. The means of AMP to limit the supply of crucial metals to micro organism as a good antibacterial process in dietary immunity is mentioned within the subsequent bankruptcy. Our present realizing of the way nutrition D, the light diet, impacts AMP-expression and the way this may impact our health and wellbeing can be addressed. final yet no longer least, the position of AMP in HIV an infection and the immunomodulatory houses of AMP spotlight the varied elements of AMP in host immunity. AMP’s particular services, together with in combating multi-resistant micro organism, recommend that they could supply healing advantages – a query that's mentioned within the ultimate chapter.
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Extra info for Antimicrobial Peptides: Role in Human Health and Disease
Cell Immunol 280:22–35 Wang G (2014) Human antimicrobial peptides and proteins. Pharmaceuticals (Basel) 7:545–594 Wang W, Owen SM, Rudolph DL et al (2004) Activity of alpha- and theta-defensins against primary isolates of HIV-1. J Immunol 173:515–520 Wiesner J, Vilcinskas A (2010) Antimicrobial peptides: the ancient arm of the human immune system. Virulence 1:440–464 Wilson SS, Wiens ME, Smith JG (2013) Antiviral mechanisms of human defensins. J Mol Biol 425:4965–4980 Wu M, Mcclellan SA, Barrett RP et al (2009) Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis.
Therefore, the proinflammatory, cytotoxic, and proproliferative functions of AMPs may also have adverse consequences by perpetuating inflammation and potentially contribute to epithelial injury in lung diseases (Shaykhiev et al. 2005; Sakamoto et al. 2005). Moreover, concentrations of AMPs have been found to be increased in severe lung diseases. Plasma concentrations of α-defensins, for instance, are increased in pulmonary fibrosis (Mukae et al. 2002) and β-defensins are increased in bronchoalveolar lavage fluids of patients with diffuse panbronchiolitis and in bronchiolitis obliterans syndrome after lung transplantation (Ross et al.
J Immunol 167:5868–5873 Lobo DS, Pereira IB, Fragel-Madeira L et al (2007) Antifungal Pisum sativum defensin 1 interacts with Neurospora crassa cyclin F related to the cell cycle. Biochemistry 46:987–996 Ma G, Greenwell-Wild T, Lei K et al (2004) Secretory leukocyte protease inhibitor binds to annexin II, a cofactor for macrophage HIV-1 infection. J Exp Med 200:1337–1346 Mathews SM, Spallholz JE, Grimson MJ et al (2006) Prevention of bacterial colonization of contact lenses with covalently attached selenium and effects on the rabbit cornea.
Antimicrobial Peptides: Role in Human Health and Disease by Jürgen Harder, Jens-M. Schröder