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With a brand new pharmacy-specific method of immunology, Immunology for Pharmacy prepares pharmacists for perform through delivering a whole figuring out of the foundation of immunology and the implications of both suppressing or bettering immune functionality. It covers key topics reminiscent of prophylaxis and vaccination, antibodies as healing and diagnostic brokers, organic modifiers, and the reason to be used and mechanisms of healing brokers.
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Extra info for Annual Review of Immunology Volume 23 2005
Although CD28 is not essential for OX40 expression, engagement of CD28 can enhance the kinetics and level of OX40 expression on T cells (54, 105). OX40 is preferentially expressed on Th2 cells in some models (106, 107), but it can also be expressed on Th1 cells (104, 107, 108) and can play a role in both Th1 and Th2 responses (to be discussed below). In vivo, OX40-expressing CD4 T cells are found in close proximity to antigen-activated B cells in the spleen (107, 109). Whereas OX40 expression appears to be restricted to T cells, OX40L is expressed on a number of cell types.
Van Lier, personal communication). CD27 is also expressed on thymocytes, and anti-CD27 treatment of mice initially suggested a role for CD27 in T cell development (70). However, these effects were not borne out in the CD27−/− mice, which have normal numbers of mature and immature T cells (71). CD70 is found on activated T cells, B cells, and DCs (16, 72–75). CD70 is induced on mouse B cells and DC by anti-CD40 or LPS and on DC by GMCSF (18). CD70 is also expressed on activated T cells but at lower levels than on activated B cells (18).
This reciprocal expression of HVEM and LIGHT on T cells (242) and the downregulation of LIGHT upon DC maturation (243) means that there is only a narrow window of time in the first few hours after initial T cell activation in which HVEMLIGHT interactions can occur. sgm LaTeX2e(2002/01/18) P1: IKH TNF FAMILY MEMBERS AS COSTIMULATORS 41 posttransplant in cardiac allografts, suggesting that in vivo both receptors and ligands can be simultaneously expressed (245). Annu. Rev. Immunol. 23:23-68. org by HINARI on 08/26/07.
Annual Review of Immunology Volume 23 2005 by Annual Reviews