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Annual Reviews's Annual Review of Immunology Volume 16 1998 PDF

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Interleukin-1 and interleukin-1 antagonism. Blood 77: 1627–52 4. Dinarello CA, Thompson RC. 1991. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today 12:404–10 5. Arend WP. 1993. Interleukin-1 receptor antagonist. Adv. Immunol. 54:167–227 6. Lennard AC. 1995. Interleukin-1 receptor antagonist. Crit. Rev. Immunol. 15:77– 105 7. Dinarello CA. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095– 147 8. Eisenberg SP, Evans RJ, Arend WP, Verderber E, Brewer MT, Hannum CH, Thompson RC.

The possible biologic role of intracellular isoforms of IL-1Ra is discussed below. Regulation of Transcription The separate 5 regulatory regions for both sIL-1Ra and icIL-1Ra have been isolated, and some of the cis-acting DNA regions involved in regulation of transcription have been characterized. A cloned 1680-bp region of the sIL-1Ra promoter exhibited a pattern of expression and induction identical to that of the endogenous gene (15). Experiments with 5 -truncated promoter constructs P1: NBL/PLB P2: NBL/plb January 19, 1998 Annu.

Using probes specific for the mRNA of each IL-1Ra isoform, icIL-1Ra mRNA was found only in the skin of normal or LPS-injected mice, as determined by ribonuclease protection assay (RPA). In addition, icIL-1Ra protein was present in the skin, as determined by Western blot analysis of skin extracts. In contrast, sIL-1Ra mRNA was not detected by RPA in any tissue of normal mice but was upregulated in the peripheral blood, spleen, lung, and liver in response to intraperitoneal injection of LPS. sIL-1Ra protein also was present in these organs as determined by ELISA and Western blot.

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