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K. 1991. Activation of functionally distinct subsets of CD4+ T lymphocytes. Res. Immunol. 142:23-32 32. Abbas, A. , Williams, M. , Burstein, H. , Lichtman, A. H. 1991. Activation and functions of CD4+T-cell subsets. Immunol. Rev. 123:5-22 33. Mueller, D. , Jenkins, M. , Schwartz, R. H. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445-80 34. Schell, S. , Fitch, F.

Bradley,L. , Weinberg, hnmunol. 140:1555-60 A. , Duncan,D. , Hedrick, S. , 16. Fiorentino, D. , Bond,M. , MosDutton, R. , Huston,G. 1991. Helper mann,T. R. 1989. Twotypes of mouse T-cell subsets: Phenotype,function and T helper cell. IV. Rev. 123: by Thl clones. J. Exp. 170: 2081115-44 95 7. Torbett,B. , Laxer,J. , Glasebrook, 17. Mosmann,T. , Schumasher, J. L. FrequenciesofT cells secretStreet, N. , ing IL-2 and/or IL-4 amongunprimed Fong, T. A. , Bond, M. , Moore, CD4+populations. Evidence that K.

Ceppellini,R. Cell mediated lympholysisin manafter sensitization of effector lymphocytesthrough mixed leukocytecultures. G. Baet. Virol. Immunol. 64:243 18. Bach,F. , Hirschhorn,K. 1964. Lymphocyteinteraction: a potential histocompatibilitytest in vitro. Science143: 813 19. , Vas, M. , L6wenstein, L. 1964. The developmentof large immatt~re mononuclearcells in mixedleukocyte cultures. Blood23:108 20. Bradley, B. , Edwards,J. , Dunn, D. , Calne, R. Y. 1972. Quantitation of mixed lymphocytereaction by gene dosage phenomenon.

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