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Get Androgen Excess Disorders in Women (Contemporary PDF

By Ricardo Azziz

ISBN-10: 1588296636

ISBN-13: 9781588296634

ISBN-10: 1597451797

ISBN-13: 9781597451796

The sphere of androgen extra problems has complicated considerably because the unique e-book of this publication. The Androgen extra Society (AES) used to be based to compile investigators within the box. a greater realizing of the screening, development, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has more advantageous the medical care and diagnostic accuracy of those sufferers. New standards for the analysis of the polycystic ovary syndrome (PCOS) have been proposed in Rotterdam, standards that experience ended in controversy and, confidently, initiation of latest reports. The organization of insulin resistance with PCOS has been bolstered, and the position of metformin in tre- ing the infertility of the PCOS has been confirmed. dangers for diabetes and, extra cont- versially, heart problems in ladies with PCOS have acquired large research. Our figuring out of the epidemiology and fiscal effect of those problems has multiplied, emphasizing their severe significance. those are yet a couple of highlights of ways the terrain has replaced in a comparatively short time period. in accordance with those advances, the identify of this ebook has been revised to mirror the turning out to be value of PCOS because the such a lot familiar androgen extra affliction in ladies, and arguably, because the person who may have the main critical hostile results for common future health. There are fewer chapters to supply a extra targeted elucidation of the world. numerous chapters have been penned by way of new (and younger) authors who're engaging in state-of-the-art learn within the box.

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1. Cholesterol is the precursor for all steroid hormones. The human adrenal and ovary can synthesize cholesterol de novo from acetate, but most cholesterol is provided by plasma low-density lipoproteins (LDLs) derived from dietary cholesterol. The presence of adequate LDL suppresses 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting step in cholesterol synthesis. HMG-CoA reductase, as well as LDL receptor number and uptake of LDL cholesterol, are stimulated by adrenocorticotropic hormone (ACTH) in the adrenal and by follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the ovary.

These two isozymes share 93% amino acid sequence identity and are encoded by tandemly duplicated genes located on chromosome 8q21-22. Both forms of P450c11 reside on the inner mitochondrial membrane and, like P450scc, utilize ferredoxin reductase and ferredoxin to receive electrons from NADPH. P450c11β is abundantly expressed in the zona fasciculata, where it catalyzes the classic 11β-hydroxylase reactions that convert 11-deoxycortisol to cortisol and DOC to corticosterone. The less abundant P450c11AS (aldosterone synthase) is uniquely expressed in the zona glomerulosa, where it catalyzes the sequential steps 11β-hydroxylase, 18-hydroxylase, and 18-methyloxidase necessary to produce aldosterone.

18. Laignel-Lavastine M. Femmes à barbe et endocrinopsychiatrie. Paris Méd 1921;41:325–333. 19. Chowne WD. Remarkable case of hirsute growth in a female. Lancet 1852;1:421–422. 20. Chowne WD. ). Lancet 1852;1:514–516. 21. Chowne WD. ). Lancet 1852;2:51–53. 22. Sampson H. , was as large as a full grown Woman; and of what appeared on the Dissection of her Body. Philos Trans R Soc 1697;19:80–82. 23. Bullock W, Siquiera JH. The relation of the suprarenal capsules to the sexual organs. Trans Pathol Soc London 1905;56:189–208.

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Androgen Excess Disorders in Women (Contemporary Endocrinology) by Ricardo Azziz


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