By Mario D. Cordero, Benoit Viollet
AMPK has emerged as an enormous integrator of indications that keep watch over power stability during the rules of a number of biochemical pathways in eukaryotes.
This publication specializes in the results of AMPK as a grasp metabolic regulator in ailments, together with new equipment and animal types. The contributions are written by means of best specialists within the box and provides an in depth evaluation of the present wisdom of AMPK biology and the function of AMPK in wellbeing and fitness and ailment.
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Cell 129 (7):1261–1274, Pubmed Central PMCID: 2756685, Epub 2007/07/03. eng Marsin AS, Bertrand L, Rider MH, Deprez J, Beauloye C, Vincent MF et al (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr Biol 10(20):1247–1255 Marsin AS, Bouzin C, Bertrand L, Hue L (2002) The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. J Biol Chem 277(34):30778–30783, Epub 2002/06/18.
PGC-1α is associated with increases in energy expenditure such as mitochondrial respiration and biogenesis as well as uptake of energy substrates (Wu et al. 1999; Lehman et al. 2000). PGC-1α exerts these effects by binding and co-activating other transcriptional factor and/or nuclear receptors to increase their expression such as ERRα, NRF1 and NRF2, and MEF2 and PPARα (Handschin and Spiegelman 2006; Vega et al. 2000). AMPK can activate PGC-1α by phosphorylation or increase its expression (Jager et al.
Even if UPS is energy consuming, the specific and UPS-dependent degradation of particular proteins could be energetically advantageous in particular circumstances. In this context, AMPK activation has been found to promote UPS process. AMPK activation results in the increase in expression of the E3 ubiquitin ligases called MuRF1 and Atrogin-1 in muscle and cardiac tissues via the regulation of different transcription factors (FoxO and MEF2) (Krawiec et al. 2007; Tong et al. 2009; Baskin and Taegtmeyer 2011).
AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet