By L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. Vingerling, C. C. W. Klaver (auth.), Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide, Alan C. Bird (eds.)
Age-related macular degeneration is the commonest reason for the lack of principal imaginative and prescient past the age of fifty in business international locations. Triplication of the variety of affected sufferers is anticipated over the following 25 years. specifically during the last years the normal of information concerning etiology, probability elements, diagnostics and treatment of this retina disorder has considerably grown – this can be coated during this updated multi-authored paintings. except epidemiologically and genetically pointed out probability components either some of the pathophysiological elements together with the position of the supplement method and scientific manifestations together with OCT and angiographic features are sincerely represented. in addition, different healing ways are awarded and mentioned, together with confirmed techniques equivalent to intravitreal anti-VEGF treatment and seeing-aid platforms, as well as the newest and upcoming tools within the sector of pharmacology. the amount is well-illustrated and tables and summaries entire the presentation.
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Science 308(5720): 421–424 59. Haines JL, Hauser MA, Schmidt S et al (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308(5720):419–421 60. Souied EH, Leveziel N, Richard F et al (2005) Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population. Mol Vis 11:1135–1140 61. Magnusson KP, Duan S, Sigurdsson H et al (2006) CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD.
The RS found that an above-median intake of these nutrients was associated with a 35% lower risk of incident AMD . 92). 97) for early AMD. 70), respectively . The BDES studied the 5-year incidence of early AMD in relation to antioxidant intake, and did not find an association. However, inverse associations were observed for the development of specific macular lesions, large drusen, and pigmentary abnormalities . AREDS reported a reduced likelihood of progression from bilateral drusen to GA with higher levels of w-3 long-chain polyunsaturated fatty acids .
Magnusson KP, Duan S, Sigurdsson H et al (2006) CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med 3(1):e5 62. Rivera A, Fisher SA, Fritsche LG et al (2005) Hypothetical LOC387715 is a second major susceptibility gene for agerelated macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet 14(21):3227–3236 63. Zareparsi S, Branham KE, Li M et al (2005) Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration.
Age-related Macular Degeneration by L. Ho, R. van Leeuwen, P. T. V. M. de Jong, J. R. Vingerling, C. C. W. Klaver (auth.), Frank G. Holz, Daniel Pauleikhoff, Richard F. Spaide, Alan C. Bird (eds.)