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Download e-book for iPad: A Time for Metabolism and Hormones by Paolo Sassone-Corsi, Yves Christen

By Paolo Sassone-Corsi, Yves Christen

ISBN-10: 3319270680

ISBN-13: 9783319270685

ISBN-10: 3319270699

ISBN-13: 9783319270692

Recent years have obvious remarkable advances within the box of circadian biology. those have attracted the curiosity of researchers in lots of fields, together with endocrinology, neurosciences, melanoma, and behaviour. by means of integrating a circadian view in the fields of endocrinology and metabolism, researchers could be in a position to exhibit many, yet-unsuspected features of the way organisms focus on alterations within the atmosphere and next keep an eye on of homeostasis. This box is beginning new avenues in our knowing of metabolism and endocrinology. A panel of the main wonderful investigators within the box accrued jointly to debate the current nation and the way forward for the sector. The editors belief that this quantity may be of use to these colleagues who should be selecting up the problem to solve how the circadian clock could be unique for the longer term improvement of particular pharmacological options towards a few pathologies.

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Nature 436:876–880 King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, Antoch MP, Steeves TD, Vitaterna MH, Kornhauser JM, Lowrey PL, Turek FW, Takahashi JS (1997) Positional cloning of the mouse circadian clock gene. Cell 89:641–653 Ko CH, Yamada YR, Welsh DK, Buhr ED, Liu AC, Zhang EE, Ralph MR, Kay SA, Forger DB, Takahashi JS (2010) Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol 8:e1000513 Koike N, Yoo SH, Huang HC, Kumar V, Lee C, Kim TK, Takahashi JS (2012) Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.

Nat Genet 38:369–374 Siepka SM, Yoo SH, Park J, Song W, Kumar V, Hu Y, Lee C, Takahashi JS (2007) Circadian mutant overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129:1011–1023 Sims RJ 3rd, Belotserkovskaya R, Reinberg D (2004) Elongation by RNA polymerase II: the short and long of it. Genes Dev 18:2437–2468 Takahashi JS, Pinto LH, Vitaterna MH (1994) Forward and reverse genetic approaches to behavior in the mouse. Science 264:1724–1733 Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, Takahashi JS (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.

28 J. Bass Although the aforementioned work has pinpointed specific defects in clock control of mitochondrial function, several unanswered questions remain in dissecting the effect of clock-NAD+ rhythms on physiology and cell biology. First, it is not yet known how NAD+ deficiency locally within skeletal muscle contributes to respiration or exercise tolerance in circadian mutant mice or in animals subjected to environmental circadian disruption. Though skeletal muscle ablation of the clock has been achieved in our group and others, the biochemical pathways through which clock abrogation impairs oxidative capacity remain largely unknown (Dyar et al.

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A Time for Metabolism and Hormones by Paolo Sassone-Corsi, Yves Christen

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